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Knudsen, L.E., Norppa, H., Gamborg, M.O., Nielsen, P.S., Okkels, H., Soll-Johanning, H., Raffn, E., Jarventaus, H. and Autrup, H. (1999) Chromosomal Aberrations in Humans Induced by Urban Air Pollution: Influence of DNA Repair and Polymorphisms of Glutathione S-Transferase M1 and N-Acetyltransferase 2. Cancer Epidemiology, Biomarkers & Prevention, 8, 303-310.

has been cited by the following article:

• TITLE: Modification of the Genetic Polymorphism of Glutathione-S-Transferase (GSTM1 and GSTT1) in Motorcycle Drivers Exposed to BTEX in Cotonou

  AUTHORS: Cachon Fresnel Boris, Sagbo H. Firmin, Nanoukon Chimène, Djedatin Gustave, Atindehou Ménonvè, Senou Maximin, Ayi-Fanou Lucie

  KEYWORDS: BTEX, Glutathione-S-Transferase, Deletion, PCR, Motorcycle Drivers

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.10 No.11, November 16, 2022

  ABSTRACT: The glutathione-S-transferase genes mainly the GSTM1 and GSTT1 alleles are responsible for the synthesis of detoxication enzymes that can remove toxic substances. The objective of this study is to seek changes in the genetic polymorphism of glutathione-S-transferase GSTM1 and GSTT1 in motorcycle drivers exposed to BTEX. Our study group consists of 60 motorcycle drivers including 30 professional and 30 non-professional. Blood samples were preleveled from the study population in the EDTA tubes and DNA was extracted by the phenol/chloroform method. The PCR technique was used to determine the presence or absence of genes. Our results showed that the percentage of GSTM1 null genotype has a statistically significant difference (P = 0.02), while the percentage of GSTT1 null genotype was non-significant (P = 0.76) between the two groups. The percentage of deletion of both genes is higher in professional than non-professional motorcycle drivers. Air pollution in Cotonou by BTEX seems to influence the deletion of the GSTM1 and GSTT1 genes at a higher percentage among professional than non-professional motorcycle drivers.