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Szilagyi, B., Eren, A., Quon, J.L., Papageorgiou, C.D. and Nagy, Z.K. (2020) Application of Model-Free and Model-Based Quality-by-Control (QbC) for the Efficient Design of Pharmaceutical Crystallization Processes. Crystal Growth & Design, 20, 3979-3996.
https://doi.org/10.1021/acs.cgd.0c00295

has been cited by the following article:

• TITLE: Production of Sucrose Crystals of Uni-Modal Size Distribution by Seeded Batch Cooling Crystallization

  AUTHORS: Norihito Doki, Shunsuke Kayamori, Masaaki Yokota, Takahiro Nemoto, Yoshikazu Kato

  KEYWORDS: Batch Cooling Crystallization, Seeding Effect, Sucrose

  JOURNAL NAME: Journal of Materials Science and Chemical Engineering, Vol.10 No.11, November 14, 2022

  ABSTRACT: From sucrose aqueous solution of high viscosity, sucrose was crystallized by seeded cooling in a batch crystallizer. At low seed loadings, the product crystal size distribution (CSD) was wide-spread because of enormous secondary and primary nucleation. However, at high seed loadings, it became uni-modal, where the crystallization was dominated by seed growth with practically no secondary nucleation. Enough seeding was thus effective in suppressing nucleation even during batch crystallization with high viscosity solution. The volume mean size of the product crystals obtained at high seed loadings agreed with that calculated by a simple mass balance assuming growth-dominated crystallization with no change in the number of crystals.