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Jia, X., Pang, P., Wang, L., Zhao, L., Jiang, L., Song, Y., Fan, X., Wang, Y., Zhao, S., Ba, J., Yang, G., Wang, X., Gu, W., Zang, L., Pei, Y., Du, J., Mu, Y. and Lyu, Z. (2020) Clinical Analysis of Preoperative Anti-Thyroglobulin Antibody in Papillary Thyroid Cancer between 2011 and 2015 in Beijing, China: A Retrospective Study. Frontiers in Endocrinology, 15, Article 452.
https://doi.org/10.3389/fendo.2020.00452

has been cited by the following article:

• TITLE: Prevalence and Clinical Significance of Preoperative Thyroglobulin Antibodies in Differentiated Thyroid Cancer Patients

  AUTHORS: Amani Matook Alhozali

  KEYWORDS: Differentiated Thyroid Carcinoma, Preoperative TgAb, Treatment Outcome, Surrogate Marker

  JOURNAL NAME: Open Journal of Endocrine and Metabolic Diseases, Vol.12 No.11, November 10, 2022

  ABSTRACT: Thyroglobulin antibody (TgAb) has been used as a surrogate tumor marker of differentiated thyroid carcinoma (DTC) patients. Preoperative TgAb (PreopTgAb) is thought to affect the prevalence, disease severity, and outcome of DTC. The objective of the present study was to retrospectively analyze the prevalence of PreopTgAb in patients diagnosed with DTC and its relation to thyroid cancer characteristics, staging, and disease outcome. A retrospective analysis of 109 DTC patients with reports of PreopTgAb was carried out. Clinicopathological parameters, including patient demographics (age and gender), TNM staging, histopathologic characteristics (type of pathology, vascular invasion, extrathyroid extension, carcinoma variant, multifocality), treatment (surgery, radioactive iodine), and outcome were recorded. The association of PreopTgAb was compared with the study variables and outcome of the disease using the Chi-square test and Mann-Whitney tests. The prevalence of PreopTgAb was 59.6%. Among the 54 PreopTgAb positive patients, 34 patients had an excellent response and 15 patients had an indeterminate response, while biochemically and structurally incomplete response was observed in 3 and 2 patients, respectively. PreopTgAb was not significantly associated with age (p = 0.919), sex (p = 0.650), pathology (p = 0.079), stage at diagnosis (p = 0.513), vascular invasion (p = 0.211), extra thyroid extension (p = 0.734), histologic variant (p = 0.877), multifocality (p = 0.361), and outcome (p = 0.360). Although we did not find a significant association between positive PreopTgAb and clinical characteristics and outcome of DTC, it can still be considered as a surrogate marker of DTC during follow-up.