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Sadek, S.A., Abbar, R.S., Atia, Z.A.M., Diaa, L.M., Naif, H.J., Jafar, K.F., Essam, Z., Sadoon, R., Ayad, R. and Kareem, G. (2020) Comparative of Chemical Methods for Determination Metronidazole—A Review. 5th Grade, Second Semester, Report, Mustansiriyah University, College of Pharmacy, Department of Pharmaceutical Chemistry, Baghdad, 5.

has been cited by the following article:

• TITLE: Influence of Some Physicochemical Exposure Factors on the Metronidazole Content of a Pharmaceutical Product: Flagyl® 250 mg Tablet

  AUTHORS: Mariette Desiree Yehe, Frédérique Yah Marie-Pierre Nikiema, Linda Hé, Vincent De Paul Ovi, Jean-Kisito Kouame, Patrick Grah Atheba, Gildas Komenan Gbassi

  KEYWORDS: Metronidazole, Influence, Physicochemistry, Content, Stability

  JOURNAL NAME: Open Journal of Physical Chemistry, Vol.12 No.3, August 30, 2022

  ABSTRACT: The present work aims to study the influence of some physicochemical parameters (light, temperature, ethanol, bile salts, potassium hydroxide, hydrogen peroxide) on the content of Metronidazole (MTZ) contained in the reference substance (SR) and in a pharmaceutical specialty Flagyl® 250 mg tablet (FLG). The method developed was linear and accurate in accordance with USP 38 and the MTZ contents were obtained by UV-visible spectrophotometry at 278 nm. These contents ranged from 225 mg to 275 mg and were thus consistent with the concentration present in the proprietary medicines (250 mg). The study of the influence of physicochemical parameters on the MTZ content in SR and FLG showed that MTZ contents are unstable in the presence of Ethanol at 96˚, KOH at 0.1N and bile salts but also when the temperature is higher than 25˚C. However, they remain stable in the presence of light and H2O2 and undergo degradation in an acidic environment.