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Esper, F.P., Adhikari, T.M., Tu, Z.J., Cheng, Y.W., El-Haddad, K., Farkas, D.H., Bosler, D., Rhoads, D., Procop, G.W., Ko, J.S., Jehi, L., Li, J. and Rubin, B.P. (2022) Alpha to Omicron: Disease Severity and Clinical Outcomes of Major SARS-CoV-2 Variants. The Journal of Infectious Diseases, 2022, jiac411.
https://doi.org/10.1093/infdis/jiac411
https://www.uptodate.com/contents/covid-19-clinical-manifestations-and-diagnosis-in-children/abstract/140

has been cited by the following article:

• TITLE: COVID-19 in Children: Experience from a Tertiary Care Hospital in Bangladesh

  AUTHORS: Kamrul Laila, Mujammel Haque, Sutopa Halder Supti, Shahana Akhter Rahman

  KEYWORDS: COVID-19 Infection, Severity, Age Group, Co-Morbid Conditions

  JOURNAL NAME: Open Journal of Pediatrics, Vol.12 No.5, November 4, 2022

  ABSTRACT: Background: Children are generally at low risk of infection and data on COVID-19 in children are scarce. This study was undertaken to document data from a tertiary care hospital in Bangladesh on the incidence, presentation and immediate outcome of COVID-19 in children. Methodology: It was a cross-sectional study conducted in the fever clinic and the department of Pediatrics, Bangabandhu Sheikh Mujib Medical University (BSMMU) over a period of one year from July 2020 to June 2021. All the RT–PCR positive pediatric cases (1 month to 18 years) were enrolled. Data were collected by a structured, predesigned and pre-tested questionnaire. Data were analyzed using Microsoft Excel spreadsheet software 2010. Frequency, percentage and chi-square tests were done for statistical analysis. Result: Among 8203 suspected pediatric COVID-19 cases, 850 (10.36%) was RT PCR positive. The highest number of RT-PCR positive COVID-19 cases was found in April 2021. More than 63% of cases were in the age group of 10 to 18 years. Male: female ratio was 0.97:1. Fever was the most common (75.9%) presenting feature followed by breathing difficulty and chest pain in 9.6% and 7% of patients respectively. Mild infection group was predominant (56.7%). Among the symptomatic cases, 16.7% were hospitalized. Oxygen inhalation and bronchodilators were needed in 75% of hospitalized patients. All the severe and critical cases were managed in the inpatient department and in pediatric PICU when indicated. Most of the patients (99.4%) improved with or without any complication. Four critically ill patients (0.75%) developed multi-organ dysfunction and expired in PICU. Conclusion: The majority of COVID-19 cases belonged to the older age group. More than 75% cases were symptomatic. History of contact was present in 78% cases. More than 99% children recovered with or without sequelae and 0.8% children with pre-existing co-morbidities expired.