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Uzrail, A.H., Assaf, A.M. and Abdalla, S.S. (2019) Correlations of Expression Levels of a Panel of Genes (IRF5, STAT4, TNFSF4, MECP2, and TLR7) and Cytokine Levels (IL-2, IL-6, IL-10, IL-12, IFN-γ, and TNF-α) with Systemic Lupus Erythematosus Outcomes in Jordanian Patients. BioMed Research International, 2019, Article ID: 1703842.
https://doi.org/10.1155/2019/1703842

has been cited by the following article:

• TITLE: The Role of IL-2, IL-4, IL-10 and IFN-γ Cytokines Expression in the Microenvironment of Cervical Intraepithelial Neoplasia

  AUTHORS: Yu Cai, Jianjun Zhai, Yumei Wu, Rui Chen, Xingyue Tian

  KEYWORDS: Cervical Intraepithelial Neoplasia, IL-2, Il-4, IL-10, IFN-γ, Vaginal Lavage Fluid

  JOURNAL NAME: Advances in Reproductive Sciences, Vol.10 No.4, October 28, 2022

  ABSTRACT: Objective: To investigate the role of IL-2, IL-4, IL-10 and IFN-γ cytokines in the microenvironment of cervical intraepithelial neoplasia. Methods: 180 patients participating were enrolled in this trial, where 50 cases are in controlgroup, 50 cases are in low-grade squamous intraepithelial lesion (LSIL) group,50 cases are in high-grade squamous intraepithelial lesion (HSIL) group, and 30 cases have cervical carcinoma. ELISA methods are used to detect the expression of IL-2, IL-4, IL-10 and IFN-γ in the lavage fluid, and all data is analyzed using one-way analysis of variance. Results: The expression of IL-2 and IFN-γ in cervical lavage fluid gradually decreases with the aggravation of the lesion. The expression of IL-4 and IL-10 increases by the aggravation of pathological changes. There were statistically significant differences in IL-2 level among the four groups. IFN-γ levels are significantly different between the cervical cancer group and the other groups, also between HSIL and LSIL group, and between HSIL and the control group, but no statistically significant difference was observed in IFN-γ e between LSIL and the control group. The expressions of IL-4 and IL-10 between the cervical cancer group and theother groups were significantly different, and also between HSIL and the control group.But there was no statistically significant difference between LSIL and the control group, HSIL and LSIL. Conclusion: The cytokines of IL-2, IL-4, IL-10 and IFN-γ in the microenvironment of the cervix play an important role in the occurrence and development of cervical intraepithelial neoplasia. This study may provide the evidence for diagnosis and treatment of cervical intraepithelial neoplasia.