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Liu, W., Cheung, Y.T., Conklin, H.M., Jacola, L.M., Srivastava, D., Nolan, V.G., Zhang, H., Gurney, J.G., Huang, I.C., Robison, L.L. and Pui, C.H. (2018) Evolution of Neurocognitive Function in Long-Term Survivors of Childhood Acute Lymphoblastic Leukemia Treated with Chemotherapy Only. Journal of Cancer Survivorship, 12, 398-406. https://doi.org/10.1007/s11764-018-0679-7

has been cited by the following article:

• TITLE: Neuro-Cognitive Functions in ALL Childhood Cancer Survivors in NCI, Cairo University, Egypt

  AUTHORS: Menna Shamma, Ahmed Kamel, Doaa R. Ayoub, Mohamed H. Fawzy

  KEYWORDS: Acute Lymphoblastic Leukemia, Neuro-Cognitive Functions, Child Behavior Checklist, Chemotherapy, Wechsler Intelligence Scale

  JOURNAL NAME: Open Access Library Journal, Vol.9 No.10, October 24, 2022

  ABSTRACT: Objective: Acute Lymphoblastic Leukemia (ALL) is one of the most common childhood malignancies, accounting for about 75% of all leukemias and a quarter all of childhood cancers, in this research we aimed at assessing neuro-cognitive consequences in children with Acute Lymphoblastic Leukemia who have been treated with chemotherapy. Methods: 95 children aged between 6 and 12 years old completed Wechsler Intelligence Scale for Children (WISC III). Sixty-one children were ALL survivors at the Pediatric Oncology Department, NCI, Cairo University compared to thirty-four were control group consisted of matching children from the same age group. Study patients have successfully accomplished their treatment protocol and were in complete remission during the evaluation for ≥ 2 years under follow up without relapse and no prediagnosis history of neuro-developmental disorder nor psychiatric disorders as evidenced by Child Behaviour Checklist (CBCL). Results: Subjects scored significantly below levels for their matched controls. The difference between patients and controls was significant (p Conclusions: Long-term sequels in neuro-cognitive functions were found in the chemotherapy only group, female patients were at higher risk than males; observed in the impairments of memory, attention, logical thinking and social knowledge.