TITLE:
The Role of Gut Microbiota in the Mechanism of Cognitive Impairment in the Elderly
AUTHORS:
Xurui Li, Yanpeng Li, Zhichao Ma, Jianguo Li
KEYWORDS:
Alzheimer’s Disease, Cognitive Impairment, Gut Microbiota, Gut Microbiota-Brain Axis
JOURNAL NAME:
Open Journal of Modern Neurosurgery,
Vol.12 No.4,
October
20,
2022
ABSTRACT: With
the aging in whole world, it has become a great challenge to explore the
relationship between the cognitive and behavioral performance of senile dementia and the underlying pathology of the brain.
Alzheimer’s disease (AD) is a common age-related and progressive neurodegenerative disease
characterized and one of the main causes of senile dementia. The pathogenesis
and treatment mechanism of AD are not completely clear. In
recent years, it has been found that the Gut microbiota (GM) disorder is
related to nervous system diseases. The objective of this review is to
summarize the etiology and pathogenyon the role of GM in the development of AD,
metabolites of GM and the occurrence of AD, and GM, diabetes and occurrence of
AD. Understanding the relationship between GM and AD will help provide possible
interventions to improve the structure of GM and prevent AD through different
treatments, and it may provide clinicians with a new and more effective way for
early diagnosis, prevention and treatment of AD.