Article citationsMore>>

Gessoni, G., Beggio, S., Barin, P., Favarato, M., Galli, C., Valverde, S., Nata, M.B., Salvadego, M.M. and Marchiori, G. (2014) Significance of Anti-HBc Only in Blood Donors: A Serological and Virological Study after Hepatitis B Vaccination. Blood Transfusion, 12, s63-s68.

has been cited by the following article:

• TITLE: Occult Hepatitis B Virus Infection: A Killer Hidden in Transfused Blood, Sudan

  AUTHORS: Elhadi Abdalla Ahmed, Abdelrahman Eldaw Mohammed, Mubarak Ahmed Elshafia, Bakri Yousif Mohamed Nour

  KEYWORDS: OBI, Blood Donors, Nested-PCR, Sudan

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.10 No.10, October 19, 2022

  ABSTRACT: Introduction: Transmission of hepatitis B virus (HBV) through the blood is a significant risk, especially in poor countries with high endemicity. Occult transmission of HBV (OBI) is an important acquisition scenario. Objective: A cross-sectional laboratory-based study followed to detect OBI in blood of accepted donors admitted to Mad Medani Blood Bank, Sudan. Methods: During the study, 200 accepted blood units were examined for HBsAg by ELISA technique and negative samples were tested for total anti-HBc antibodies using electroluminescence immunoassay (ECLIAS). HBV DNA amplification was performed for units that showed total anti-Hbc positivity. Results: Of the 200 blood units, 3 appeared positive by ELISA. Total anti-HBc antibodies were present in 34% (67/197) of blood units. HBV DNA was successfully amplified in 52.2% (35/67) of total anti-HBc positive samples. A significant association was observed between reactive total anti-HBc and age group (p Conclusion: OBI was recorded at a high rate in the blood of donors, which necessitates the implementation of detection methods to protect the recipients.