TITLE:
Slow and Steady: The Cautious Use of Neuroleptics in a Patient with Andersen-Tawil Syndrome
AUTHORS:
Fahad Alkhalfan, Bharadwaj Adithya-Sateesh, Girma M. Ayele, Merve Otles, Rediet T. Atalay, Miriam Michael
KEYWORDS:
Long Q-T Schizophrenia, Neuroleptic, Anderson Tawil Syndrome, Congenital Long QT Syndrome
JOURNAL NAME:
Case Reports in Clinical Medicine,
Vol.11 No.10,
October
9,
2022
ABSTRACT: Long QT syndrome (LQT) is a disease of cardiac repolarization caused by alterations in the transmembrane potassium and sodium currents. This results in prolongation of the QT interval on electrocardiography (EKG) and can result in torsade de pointes and sudden cardiac death. We present a case of a patient who has Anderson Tawil syndrome; a congenital long QT syndrome, with a history of cardiac arrhythmias who developed acute paranoid schizophrenia that was refractory to treatment with non-QT-prolonging drugs and required institution of neuroleptics to control her psychiatric symptoms.