TITLE:
Genistein Mitigates the Gastro-Toxic Effects of Bisphenol A in Male Wistar Rats
AUTHORS:
Abayomi Oluwatosin Ige, Olayinka Oyinkansola Adebayo, Bernard Omokheshi Adele, Anthony Olusoji Odetola, Idara Emmanuel Emediong, Elsie Olufunke Adewoye
KEYWORDS:
Bisphenol A, Genistein, Stomach, Gastro-Protection, Gastric Impairment
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.10 No.9,
September
9,
2022
ABSTRACT: Exposure to Bisphenol A (BPA) worldwide is on the increase. Its toxicities in various tissues expressing estrogen receptors have been reported. However, limited information exists on its effects on the gastric tissue. This study therefore investigated the gastric effects of BPA exposure and the likely ameliorative potential of genistein, a phytoestrogen antioxidant, known to interact with estrogen receptors. Eighty-four male Wistar rats were randomly divided into 6 groups (n = 14) and orally treated for 28 days. Group I-IV received distilled water (0.2 ml), corn oil (3 ml/kg), BPA (50 mg/kg) and genistein (50 mg/kg) respectively. Group V was pre-treated daily with BPA one hour prior to genistein administration while Group VI was pre-treated daily with genistein one hour prior to BPA treatment. Thereafter, blood was collected into heparinized bottles for hematological analysis. Gastric juice was collected for pH and electrolytes determination. Gastric tissue was excised and analyzed for superoxide dismutase (SOD), reduced glutathione (GSH), malondialdehyde, nitric oxide (NO), mucin, parietal and mucous cell counts, and histology. The BPA only treatment group exhibited significant increases (p