TITLE:
Colorectal Cancer in the Oncology Department at the Joseph Ravoahangy Andrianavalona, Antananarivo, Madagascar: Retrospective Study
AUTHORS:
Toky Rakotoarivo, Malala Razakanaivo, Mirana Christiana Ranaivoson, Ny Ony Andrianandrasana, Florine Rafaramino
KEYWORDS:
Colorectal Cancer, Surgery, Chemotherapy, Radiotherapy, Antananarivo
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.8,
August
25,
2022
ABSTRACT: Introduction: Colorectal cancer is one of the most common causes of cancer morbidity.
The epidemiological and therapeutic data available are very limited in
Antananarivo. The aim of this study was to provide an updated report on the
management of colorectal cancer and know the survival of patients. Patients and Methods: A descriptive retrospective study during 2018 and
2019 carried out in the oncology department of Joseph Ravoahangy Andrianavalona
Antananarivo Hospital. Newly diagnosed patients with histological evidence were
included in the study. Results: Sixty-five cases of cancer were collected, including 39 colon cancers
and 26 rectal cancers. The average age was 53 years with extremes of 18 and 83
years. In 41.53%, the patients were young people under 50 years old. The sex
ratio was 0.95. Four patients (6.15%) had a
family history of first degree cancer. The left colon was the most
common location in 43.06% of cases. Only 39% of patients were diagnosed within
6 months of the first symptoms. The most common histological type was
lieberkuhnian adenocarcinoma (87.69%). None of the patients underwent an
immunohistochemistry examination. Stage IV and III accounted for 41.53% and 35.38% respectively. The majority
(55.38%) of patients had benefited from surgery. Chemotherapy was
performed in 56.89% of cases. One metastatic patient had received targeted
therapy. Nine patients (34.61%) among the 26 with rectal cancers had benefited from
concomitant radiochemotherapy. Survival at 30 months was 20%. Conclusion:
The survival rate of patients at 30 months is very low. Improving the
management of colorectal cancer requires awareness-raising and early detection.