TITLE:
Locally Advanced Breast Cancer in Pakistani Women: What Is Different from Rest of the World and Why It Is Difficult to Manage
AUTHORS:
Muhammad Khalid, Noor Ul Wara Rao, Farwa Batool Shamsi, Tayaba Kanwal, Sana Arshad, Muhammad Shahzeb, Ameer Alam, Sobia Aleem, M. Ahsan Iqbal
KEYWORDS:
Oncology Breast, Cancer in Pakistani Women, LABC
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.8,
August
24,
2022
ABSTRACT: Locally
Advance Breast Cancer refers to a heterogeneous group of breast cancer with
locally extensive disease, which may or may not involve the nodes,
without any distant metastases. The study was conducted at Faisalabad Medical
University (FMU), Oncology, Allied Hospital Faisalabad (Pakistan). Data of 100
patients with LABC was collected. Demographics were recorded in the form of age, socio-economic status. In clinical
data, time of presentation, family history of breast cancer, the
presenting symptom in the form of lump, ulceration and other skin changes were
noted. Histo-pathological variables including tumor size, histopathology, Bloom
& Richardson grading, estrogen receptor
(ER), progesterone receptor status (PR) and HER2 status. Results showed
that after following a standard trimodality treatment approach in LABC
patients, 30 percent died within two years. Disease free survival for more than
two years was observed in only 25% of patients. Whereas, 70% patients had
eventful (Recurrence/metastases) survival. This poor outcome was observed due
to lack of health care facilities, awareness and poor socioeconomic status.