TITLE:
A Comparative Study of Antifatigue Effects of Taurine and Vitamin C on Chronic Fatigue Syndrome
AUTHORS:
Shin-Hee Kim, Hyun-Jin Kim, Semi Kim, Ju-Seop Kang, Young Tae Koo, Sang Hun Lee, Dong-Hyun Paik
KEYWORDS:
Vitamin C, Taurine, Chronic Fatigue Syndrome, Anti-Fatigue Effect
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.13 No.8,
August
22,
2022
ABSTRACT: Vitamin C and taurine (TR) are well known as active components for fatigue recovery. However, the mechanism of the anti-fatigue effects of vitamin C and TR is still unclear. Our study was designed to evaluate the anti-fatigue activities of vitamin C and TR in an animal test for fatigue and to compare the activities between vitamin C and TR. Materials and Methods: Vitamin C, TR or their combination were orally administrated to mice once daily for 15 days, and then metabolic activities such as blood glucose, triglyceride (TG), lactate, and lactate dehydrogenase (LDH) as well as antioxidant activities such as malondialdehyde (MDA) and superoxide dismutase (SOD) were determined (evaluated) after forced swimming test (FST). Results: Compared with the control group, C100, C200, and T50 showed a tendency to decrease mobility in FST. Moreover, TG (C100, C200, T200), LDH (C200), lactic acid (C100) and MDA (C50, C100, C200) levels were inhibited by vitamin C and TR. Conclusions: These results suggest that vitamin C and TR have anti-fatigue activities in mice, with vitamin C providing a stronger effect.