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Elalfy, H.Y., Elsamkary, M.A., Elridy, A.M.S., Saad, T.M., Rashad, S.M. and Fawzy, S.M. (2020) Medical Treatment of Inflammatory Punctual Stenosis Monitored by Anterior Segment Optical Coherence Tomography. International Journal of Ophthalmology, 13, 1074-1078. https://doi.org/10.18240/ijo.2020.07.09

has been cited by the following article:

• TITLE: Topical Cyclosporine-A for Management of Epiphora in Eyes with Acquired Punctal Stenosis

  AUTHORS: Mona Abdelhamid Nassief, Ameera Gamal Abdelhameed, Sherein Mahmoud Hagras

  KEYWORDS: Cyclosporine A, Epiphora, Munk Grading, Ocular Surface, Punctal Stenosis

  JOURNAL NAME: Open Journal of Ophthalmology, Vol.12 No.3, August 19, 2022

  ABSTRACT: Background: Cyclosporine A (CsA) is an inhibitor of calcineurin that prevents T-cell production of inflammatory cytokines and disrupts the immune-mediated inflammatory response that plays a crucial mechanism in punctal stenosis. Purpose: To evaluate the clinical outcomes and tolerances of CsA in treating epiphora in eyes with punctal stenosis. Study Design: Prospective study. Methods: The study included patients who presented with symptomatic epiphora associated with lower punctal stenosis during the period between July 2019 and December 2020. Patients were treated with topical 0.05% CsA on twice daily dose with topical preservative-free artificial tears Q.I. D. Patients were followed up monthly for at least 3 months by Munk epiphora grading, Fluorescein dye disappearance test (FDT) and evaluation of the patient satisfaction. Results: A total of 26 patients with 47 eyes were included in the study with a mean age of 55.1 ± 10.24 years. All the eyes had grade 0 lower punctal stenosis with grade 4 on Munk grading and grade 3 in FDT. There was a statistically significant difference in the Munk grading and FDT along the follow-up period compared to the baseline values (p rd month. None of the patients encountered any complications during treatment. Conclusion: CsA can control the inflammation of the conjunctival sac and restore the integrity of the ocular surface with subsequent symptomatic relief of the epiphora in eyes with punctal stenosis.