TITLE:
Acute Renal Failure Secondary to Paracetamol Intoxication: A Case Report
AUTHORS:
Moctar Coulibaly, Magara Samaké, Konaré Samba, Fofana Aboubacar Sidiki, Ossil Ampion Marc, Batcho Jimmy, Mansour Janette, Seydou Sy, Hamadoun Yattara, Atabième Kodio, Djénéba Maiga, Sah Dit Baba Coulibaly, Djénèba Diallo, Aboudou M. Dolo, Moustapha Tangara, Nouhoum Coulibaly, Kalilou Coulibaly, Ibrahima Koné, Saharé Fongoro
KEYWORDS:
Acute Renal Failure, Paracetamol Intoxication, Hemodialysis
JOURNAL NAME:
Open Journal of Nephrology,
Vol.12 No.3,
July
29,
2022
ABSTRACT: Renal damage secondary to paracetamol intoxication is rare, estimated between 1% and 2% of intoxication cases. Its pathophysiology is still debated, the clinical involvement consisting in an acute tubular necrosis with a good prognosis if it is rapidly treated. Renal damage can sometimes occur without prior hepatic damage, and the onset of renal manifestations is generally between the 2nd and 7th day after taking paracetamol. If its management remains exclusively symptomatic, its late onset can sometimes lead to serious metabolic complications. It is therefore important to systematically monitor renal function following paracetamol drug intoxication. We report the case of a 60-year-old male subject hospitalized for the management of voluntary drug intoxication (VDI) with paracetamol complicated by acute hepatocellular failure and acute renal failure. His management required extrarenal purification (hemodialysis) and the evolution was favorable with recovery ad integrumof renal function. Conclusion: Although less known and of unelucidated physiopathology, nephrotoxicity secondary to voluntary drug intoxication with paracetamol is a reality and can lead in extreme cases to the use of extrarenal purification technique (hemodialysis).