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Rao Kondapally Seshasai, S., Kaptoge, S., Thompson, A., Di Angelantonio, E., Gao, P., Sarwar, N., Whincup, P.H., Mukamal, K.J., Gillum, R.F., Holme, I., Njolstad, I., Fletcher, A., Nilsson, P., Lewington, S., Collins, R., Gudnason, V., Thompson, S.G., Sattar, N., Selvin, E., Hu, F.B. and Danesh, J. (2011) Diabetes Mellitus, Fasting Glucose, and Risk of Cause-Specific Death. The New England Journal of Medicine, 364, 829-841.
https://doi.org/10.1056/NEJMoa1008862

has been cited by the following article:

• TITLE: Alterations of Blood Immune Cells in Elderly Patients with COVID-19 and with or without Pre-Existing Type 2 Diabetes

  AUTHORS: Susana Salva, Yanina Kolling, Nicolás Argañaraz, María Pía Rocchia Novillo, María del Milagro Rocchia Novillo, Leonardo Albarracin, Jacqueline Charubi, Alejandra Casen, Nadia Gobbato, Mirta Rachid, Susana Alvarez, Haruki Kitazawa, Julio Villena, Juan Carlos Valdez

  KEYWORDS: COVID-19, SARS-CoV-2, Diabetes, Elderly, Blood Leukocytes, Immune Response

  JOURNAL NAME: Open Journal of Immunology, Vol.12 No.2, June 30, 2022

  ABSTRACT: Elderly individuals, especially those with pre-existing conditions like type 2 diabetes mellitus (T2DM), have a high risk for developing severe cases of COVID-19. The aim of this work was to characterize the alterations of blood immune cells (BIC) in patients with symptomatic COVID-19 and confirmed SARS-CoV-2 infection, ≥60 years and who needed hospitalization in the Centro de Salud Hospital of Tucuman, Argentina, during the second peak of the pandemic in Argentina. Ten patients were enrolled from December 2020 to May 2021. Blood samples were taken at the time of admission (day 0) and five days after (day 5) for routine laboratory tests and the characterization of BIC by flow cytometry. Most of the patients were men (70%) aged between 60 and 78 years. The 70% of patients had T2DM while 50% had arterial hypertension. At day 0, all the patients had increased neutrophils and inflammatory markers (C reactive protein and D-dimers) and reduced numbers of lymphocytes, HLA-DRhi monocytes, CD16+CD56+ NK cells, CD3+HLA−DR+CD25+ cells, CD4+ and CD8+ T cells in blood. Patients received a standard treatment for COVID-19 care (O2, corticosteroids and antibiotics). The hospital treatment normalized the levels of BIC (day 5) in 30% of patients who were those with no comorbidities. In patients with T2DM, BIC recovery was variable. In T2DM patients who required administration of plasma (30%), prolonged O2 therapy (40%) or referral to the intensive care unit (10%) significant reductions of CD16+CD56+, CD3+HLA−DR+CD25+, CD4+ and CD8+ cells were observed between days 0 and 5. In line with previous studies, our results show that absolute counts of major lymphocyte subsets in blood are significantly and substantially decreased during the course of severe COVID-19 disease in elderly patients. These BIC alterations may persist despite clinical care in elderly patients with T2DM. Further studies are needed to investigate the utility of early lymphocyte subset measurements as prognostic biomarkers of disease severity, mortality, and response to treatment in COVID-19 elderly patients with T2DM.