TITLE:
Left Ventricular Diastolic Dysfunction and Silent Myocardial Ischemia amongst Asymptomatic Type 2 Diabetic Patients in Two Referral Hospitals in Cameroon
AUTHORS:
Joshua Njimbuc Walinjom, Jerome Boombhi, Martine Etoa, Collins Chenwi Ambe, Emerentia Eho, Alain Menanga, Samuel Kingue
KEYWORDS:
Asymptomatic Cardiovascular Manifestations, Left ventricular Diastolic Dysfunction, Silent Myocardial Ischemia, Type 2 Diabetes, Cameroon
JOURNAL NAME:
World Journal of Cardiovascular Diseases,
Vol.12 No.7,
July
18,
2022
ABSTRACT: Background: Cardiovascular events, the leading cause of death among diabetic patients, are usually under-diagnosed due to subclinical presentation. Methods: We conducted a cross-sectional study from March-2019 to September-2020, in two reference hospitals in Yaoundé, Cameroon, to assess the prevalence of asymptomatic Left Ventricular Diastolic Dysfunction (LVDD) and Silent Myocardial Infarction (SMI) and potentially associated factors. Results: Out of 95 participants (mean age ± SD: 43 ± 7 years; M/F sex-ratio 1.6), 22 (23.1%; 95% CI: 15.8% - 32.6%) had LVDD and fewer (n = 13, 13.6%; 95% CI: 8.2% - 22.0%) had SMI, p = 0.86. Though not statistically significant, patients with ≥5 years diabetes duration, as well as patients with HbA1C ≥ 7.5% had two-fold increased risk of LVDD (p = 0.22 and p = 0.15 respectively). LVDD was significantly higher in patients with SMI (29% vs 6.3%, p Conclusion: The significant presence of asymptomatic cardiovascular manifestations in this population entails mandatory preventive screening, especially, in patients with long standing diabetes and poor glycemic control, to allow timely detection and management.