TITLE:
Association Study of Thyroid Papillary Carcinoma with Depression and BDNF Expression
AUTHORS:
Hongbiao Lin, Kunmei Wu, Xinguang Zhang, Xingjie Huang, Chongcai Wu, Haixiang Cai
KEYWORDS:
Papillary Thyroid Carcinoma, Depressive Disorder, Brain-Derived Neurotrophic Factor, Polymerase Chain Reaction
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.7,
July
15,
2022
ABSTRACT: Objective: To analyze the correlation between Val66Met gene of brain-derived neurotrophic factor
(BDNF) and papillary thyroid carcinoma (PTC) complicated with depression. To
evaluate the clinical value of papillary thyroid carcinoma. Methods: Self-rating
Anxiety Scale (SAS) and Self-rating Depression Scale (SDS) were used to assess
the correlation of BDNF in the blood of patients with depressive disorder of
thyroid papillary carcinoma using polymerase chain reaction PCR. The
relationship between BDNF gene polymorphism and the incidence of thyroid
papillary carcinoma was analyzed, and the susceptibility factors of thyroid
papillary carcinoma complicated with depression were explored. Results: Compared
with normal control group, T3 and T4 of PTC in non-depressed group were
decreased, while TSH and TPOAb were increased (P Conclusion: There is a significant
difference between PTC with depression and PTC without depression, which is
related to SNP rs6265 of BDNF gene. AG and GG are both risk sites of PTC with
depression, and GG type is more prone to PTC with depression.