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Naoto, M., Toshinari, T., Hitoshi, A., Seiji, N., Seichiro, K., Hirfumi, M., Tsuguhito, O., Masyoshi, Y., Masao, H., Ken-Ichi, M. and Shuichi, K. (2008) Increased Oxidative Stress Precedes the Onset of High-Fat-Diet-Induced Insulin Resistance and Obesity. Metabolism, 57, 1071-1077.
https://doi.org/10.1016/j.metabol.2008.03.010

has been cited by the following article:

• TITLE: Omega 3 Fatty Acid and Cannabidiol Prolong Lifespan and Ameliorates Brain Ischaemia in Mice Fed Chronic High Fat Diet

  AUTHORS: Innocent Abi, Aver Maria Yongu, Ugbudu George Tersoo, Olasupo Stephen Adeniyi, Linus Chia Saalu

  KEYWORDS: Omega 3, CBD, HFD, Lifespan, Astrocytosis

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.12 No.7, July 5, 2022

  ABSTRACT: Diets these days contain more fats. High fat diet (HFD) is a model of unhealthy eating in experimental animals. It is known to induce inflammatory responses and oxidative stress. Cannabidiol (CBD), the non-psychoactive component of Cannbis sativa has been legalized for medicinal use in many countries of the world. Omega 3 fatty acid, commonly found in fish oil is medicinal and necessary for brain development. The antioxidant and neuroprotective functions of CBD and omega 3 have made them relevant in many researches. In this study, 45 mice were used and divided into three groups of 15 animals each: Group 1 (normal feed and water ad libidum); Group 2 (HFD ad libidum); Group 3 (HFD + CBD + Omega 3) for 16 weeks. Thereafter, five animals from each group were selected and their frontal lobes were harvested for histological analyses using H and E staining. The remaining mice were allowed to feed on normal diet and observed till death. At the end, HFD significantly reduced life span (57.4 ± 0.3) when compared to control (78.9 ± 1.6) and HFD + CBD + omega 3 group (74.5 ± 0.8) at p