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Demler, O., Liu, Y., Watrous, J., Gibson, H., Lagerborg, K., Dashti, H., Heath, M., Camargo, C.A., Harris, W.S., Wohlgemuth, J.G., Najhawan, M., Dao, K., Prentice, J., Larsen, J.A., Okereke, O., Costenbader, K., Buring, J.E., Ramachandran, V.S., Manson, J.E., Cheng, S., Jain, M. and Mora (2019) Abstract 13189: Effects of Marine Omega-3 Supplementation on Fatty Acids and Bioactive Lipids and Associations with Risk of Cardiovascular Disease: Secondary Analysis from the Randomized Vitamin D and Omega-3 Trial (VITAL). Circulation, 140, A13189.

has been cited by the following article:

• TITLE: Omega 3 Fatty Acid and Cannabidiol Prolong Lifespan and Ameliorates Brain Ischaemia in Mice Fed Chronic High Fat Diet

  AUTHORS: Innocent Abi, Aver Maria Yongu, Ugbudu George Tersoo, Olasupo Stephen Adeniyi, Linus Chia Saalu

  KEYWORDS: Omega 3, CBD, HFD, Lifespan, Astrocytosis

  JOURNAL NAME: Journal of Behavioral and Brain Science, Vol.12 No.7, July 5, 2022

  ABSTRACT: Diets these days contain more fats. High fat diet (HFD) is a model of unhealthy eating in experimental animals. It is known to induce inflammatory responses and oxidative stress. Cannabidiol (CBD), the non-psychoactive component of Cannbis sativa has been legalized for medicinal use in many countries of the world. Omega 3 fatty acid, commonly found in fish oil is medicinal and necessary for brain development. The antioxidant and neuroprotective functions of CBD and omega 3 have made them relevant in many researches. In this study, 45 mice were used and divided into three groups of 15 animals each: Group 1 (normal feed and water ad libidum); Group 2 (HFD ad libidum); Group 3 (HFD + CBD + Omega 3) for 16 weeks. Thereafter, five animals from each group were selected and their frontal lobes were harvested for histological analyses using H and E staining. The remaining mice were allowed to feed on normal diet and observed till death. At the end, HFD significantly reduced life span (57.4 ± 0.3) when compared to control (78.9 ± 1.6) and HFD + CBD + omega 3 group (74.5 ± 0.8) at p