Article citationsMore>>

Olagunju, A., Amara, A., Waitt, C., Else, L., Penchala, S.D., Bolaji, O., et al. (2015) Validation and Clinical Application of a Method to Quantify Nevirapine in Dried Blood Spots and Dried Breast-Milk Spots. Journal of Antimicrobial Chemotherapy, 70, 2816-2822.
https://doi.org/10.1093/jac/dkv174

has been cited by the following article:

• TITLE: Development, Validation and Application of a Spectrofluorimetric Method for the Quantification of Nevirapine in Pharmaceutical Formulations Tablets and Suspensions

  AUTHORS: Lucien Murhula Namegabe, Aladin Ombeni Mahano, Serigne Omar Sarr

  KEYWORDS: Spectrofluorimetric Method, Validation Nevirapine, Sodium Hypochlorite

  JOURNAL NAME: American Journal of Analytical Chemistry, Vol.13 No.6, June 30, 2022

  ABSTRACT: The development of the spectrofluorimetric method can be considered a promising alternative that is relatively less expensive and sufficiently reliable. In the current literature, no method for the analysis of nevirapine by spectro-fluorimetric has been reported. The proposed method is based on the transformation of naturally non-fluorescent nevirapine into a fluorescent derivative after chemical synthesis. Maximum excitation and emission wavelengths are 290 nm and 357 nm respectively. The analytical performance of the method demonstrates linearity in the concentration range 1.5 × 10-2 and 13.5 × 10-2 μg/mL with a correlation coefficient (r) greater than 0.999. The detection (LOD) and quantification (LOQ) limits found are 1.97 × 10-3 μg/mL and 5.48 × 10-3 μg/mL respectively. Recovery is achieved with 99.9% and 100.3% trueness, intra-day precision with a coefficient of variation of repeatability (CVr) of 0.99% and inter-day precision with a coefficient of variation of precision (CVR) of 1.7%. The method has been successfully applied in the analysis of 10 batches of nevirapine tablets and suspensions.