TITLE:
Antidiabetic Potential of Carthamus oxycantha M.Bieb. Seeds in Alloxan Induced Diabetic Rats
AUTHORS:
Ali Imran Abid, Hira Muzammel, Humera Shafi, Mouqadus Un Nisa, Hassan Ali, Muhammad Waqar Afzal, Nadeem UL Hassan Khan, Fahad Muzammil
KEYWORDS:
Diabetes Mellitus, Carthamus oxycantha, Alloxan, Glibenclamide, AEECO
JOURNAL NAME:
Pharmacology & Pharmacy,
Vol.13 No.6,
June
30,
2022
ABSTRACT: Ethnopharmacological Relevance: Diabetes Mellitus is one of the most common
disorders of metabolic abnormalities. It is characterized by hyperglycemia
followed by abnormalities in insulin release, insulin work, or both. This persistent
hyperglycemia is concerned with long-term complications, dysfunction and
collapse of various organs, notoriously the kidneys, heart, nerves, blood
vessels and eyes. The seeds of the Carthamus
oxycantha have been used by the practitioners as a traditional remedy for
diabetes mellitus in the rural areas of district Jhang as well as other areas
of Pakistan. Aim of the Study: The purpose of the present study was to reveal the antidiabetic
capability of seeds of Carthamus
oxycantha in short-term and long-term studies. Materials
and Methods: Aqueous ethanolic extract of seeds was prepared by a rotary evaporator. The antidiabetic activity of the
seeds was assessed by using normoglycemic and glucose loaded rats. However, two
kinds of studies i.e. short-term as well as long-term treatment were carried out in alloxan induced
diabetic rats for the finalized both doses i.e. 50 mg/kg and 100 mg/kg. Blood samples were tested by an electrochemical
technique using a glucometer. Results: The promising results were achieved for the antidiabetic potential of the
ethanolic extract of seeds of Carthamus
oxycantha at both of the doses i.e. 50 mg/kg and 100 mg/kg. The antihyperglycemic potential was also evaluated in
normoglycemic and glucose loaded animals. Treatment with 100 mg/kg AEECO
presented significant reduction (p the standard drug Glibenclamide at 0.5 mg/kg.
Phytochemical studies of AEECO also disclosed the presence of flavonoids,
resins, glycosides, steroids and alkaloids. In conclusion, the antidiabetic properties of AEECO may be
attributed either due to the release of insulin or possibly due to the peripheral uptake of glucose. It may also be due to
protection of beta cells from toxic effects of alloxan or the presence of flavonoids may exhibit various
biological activities as they have been stated for their antidiabetic
potential. However, further studies are required to explore the active moieties
responsible for antidiabetic potential.