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Gadzinski, J.A., Guo, J., Philips, B.J., Basse, P., Craig, E.K., Bailey, L., et al. (2016) Evaluation of Silicon Phthalocyanine 4 Photodynamic Therapy Against Human Cervical Cancer Cells in Vitro and in Mice. Advances in Biological Chemistry, 6, 193-215. https://doi.org/10.4236/abc.2016.66017

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• TITLE: Synthesis, Photophysical Properties and DNA-Photocleavage Activity of Silicon Phthalocyanine Derivatives

  AUTHORS: Kunhui Sun, Yanli Ge, Jun Yang, Xuelei Hu

  KEYWORDS: Silicon Phthalocyanine, Fluorescence Quantum Yield, Singlet Oxygen Quantum Yield, DNA-Photocleavage Activity

  JOURNAL NAME: Pharmacology & Pharmacy, Vol.13 No.6, June 30, 2022

  ABSTRACT: Silicon phthalocyanine derivatives 1a and 1b were synthesized and characterized by UV, 1H-NMR and MS. The photophysical properties of the compounds in DMSO were investigated. The maximum absorption peaks of compounds 1a and 1b at the Q-band are 681 nm. With ZnPc (ΦF = 0.20, ΦΔ = 0.67) as a reference, the fluorescence quantum yield (ΦF) of 1a and 1b are 0.20 and 0.31 respectively, and the singlet oxygen quantum yield (ΦΔ) are 0.66 and 0.59 respectively. The DNA-photocleavage activities of compounds 1a and 1b were studied by gel electrophoresis. Compounds 1a and 1b possess good photocleavage activity to pBR322 DNA. The results demonstrate that compounds 1a and 1b are potential photosensitizers for tumor therapy.