TITLE:
A New Observation of Bone Marrow Involvement by Diffuse Large B-Cell Lymphoma Mimicking Myelofibrosis
AUTHORS:
Fall Seynabou, Alioune Badara Diallo, Dibor Niang, El Hadji Daouda Niang, Khadim Sarr, Marième Lolita Camara, Abibatou Sall, Fatou Samba Ndiaye
KEYWORDS:
Diffuse Large B-Cell Lymphoma, Myelofibrosis, Rituximab
JOURNAL NAME:
Open Journal of Blood Diseases,
Vol.12 No.2,
June
30,
2022
ABSTRACT: Diffuse large B-cell lymphoma (DLBCL) is the most common non-Hodgkin lymphoma, characterized by high clinical and biological heterogeneity. Patients typically present with progressive lymphadenopathy, extranodal disease and may also experience fever, night sweats and unexplained weight loss. We report here the case of a 16-year-old female with osteoarticular pain, dizziness, and dyspnea on exertion. Clinical examination showed no lymphadenopathy. Complete blood count (CBC) revealed pancytopenia and marrow smears found to be hypocellular. Initial diagnosis favored secondary myelofibrosis. Diagnosis of bone marrow involvement by DLBCL was retained on bone marrow histology and immunohistochemistry which showed infiltration of large B lymphoid cells. The patient was treated by immunochemotherapy R-CHOP regimen. This case highlights a very rare and atypical circumstance of discovery of DLBCL with myelofibrosis as an initial symptom. Prognosis value of this presentation and management difficulties are also discussed.