TITLE:
Sarcomatoid Carcinoma of the Mandible: A Case Report and Literature Review
AUTHORS:
Kenza Benali, Tayeb Kebdani, Khalid Hassouni, Sanaa El Majjaoui, Hanan El Kacemi, Noureddine Benjaafar
KEYWORDS:
Sarcomatoid Carcinoma, Mandible, Adjuvant Chemoradiation, VMAT
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.6,
June
21,
2022
ABSTRACT: Background: Sarcomatoid carcinoma is a rare biphasic malignancy with an epithelial
and mesenchymal component. Given its histological particularity, the diagnosis
of this tumor still represents a challenge for pathologists and surgeons.
Sarcomatoid carcinoma of the mandible is a very rare and aggressive entity. To
date, only sporadic cases have been reported in the literature. Aim: To
report a rare case of aggressive mandibular sarcomatoid carcinoma treated with
radical surgery and adjuvant chemoradiation, and discuss the related
literature. Case Report: We introduce a rare case of mandibular
sarcomatoid carcinoma occurring in a 34-year-old woman. Treatment consisted of
radical surgery and re-excision for positive margins, adjuvant radiation
therapy (66 Gy in 33 fractions in simultaneous integrated boost delivered using
Volumetric Modulated Arc Therapy) and Cisplatin-based concurrent chemotherapy.
The tumor displayed aggressive behavior and high metastatic potential, causing
tumour recurrence and extensive lung metastasis. Conclusion: Sarcomatoid
carcinoma of the mandible is an extremely rare malignant entity, with a high
tendency for local recurrence, distant metastasis. Treatment involves radical
surgery and adjuvant chemoradiation, although the outcome and prognosis might
be poor.