TITLE:
Salivary Active MMP-2 of Breast Cancer Patients Is Inhibited by Guava Leaves PBS Extract
AUTHORS:
Ramanuj Mukherjee, Syandan Sinha Ray, Subhajit Mondal, Amitava Chatterjee
KEYWORDS:
MMP-2, Inhibitor, Saliva, Breast Cancer
JOURNAL NAME:
American Journal of Plant Sciences,
Vol.13 No.5,
May
30,
2022
ABSTRACT: Matrixmetalloproteinase-2 (MMP-2), also called
gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a
zinc binding protein, responsible for the degradation of Extra Cellular Matrix
(ECM) in normal physiological as well as disease processes like arthritis and
cancer. It has a specific role in the cancer development and angiogenesis.
MMP-2 contributes to cell migration. MMPs are the key to normal development as
well as in the pathology of cancer and other inflammatory diseases. The
inhibitors of MMP-2 activity are very important in maintaining the normal
activity of MMP-2 and have an important role in the management of cancer.
Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report,
we are discussing about a possible inhibitor(s) present in the PBS extract of
guava leaves, inhibiting the active MMP-2 present in the saliva of breast
cancer patients.