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Webb, A.H., Gao, B.T., Goldsmith, Z.K., Irvine, A.S., Saleh, N., Lee, R.P., et al. (2017) Inhibition of MMP-2 and MMP-9 Decreases Cellular Migration, and Angiogenesis in in Vitro Models of Retinoblastoma. BMC Cancer, 17, 1-11.
https://doi.org/10.1186/s12885-017-3418-y

has been cited by the following article:

• TITLE: Salivary Active MMP-2 of Breast Cancer Patients Is Inhibited by Guava Leaves PBS Extract

  AUTHORS: Ramanuj Mukherjee, Syandan Sinha Ray, Subhajit Mondal, Amitava Chatterjee

  KEYWORDS: MMP-2, Inhibitor, Saliva, Breast Cancer

  JOURNAL NAME: American Journal of Plant Sciences, Vol.13 No.5, May 30, 2022

  ABSTRACT: Matrixmetalloproteinase-2 (MMP-2), also called gelatinase-A, is a 72 Kd protein present in chromosome 16 in human. It is a zinc binding protein, responsible for the degradation of Extra Cellular Matrix (ECM) in normal physiological as well as disease processes like arthritis and cancer. It has a specific role in the cancer development and angiogenesis. MMP-2 contributes to cell migration. MMPs are the key to normal development as well as in the pathology of cancer and other inflammatory diseases. The inhibitors of MMP-2 activity are very important in maintaining the normal activity of MMP-2 and have an important role in the management of cancer. Regulation of MMP-2 activity is done by inhibitors like, TIMPs. In this report, we are discussing about a possible inhibitor(s) present in the PBS extract of guava leaves, inhibiting the active MMP-2 present in the saliva of breast cancer patients.