TITLE:
Methylene Tetra-Hydrofolate Reductase Gene Polymorphism and Endometrial Perfusion in Unexplained Female Infertility
AUTHORS:
Eman Aly Abd El Fattah
KEYWORDS:
Unexplained Infertility, Uterine Doppler, MTHFR Gene Polymorphism
JOURNAL NAME:
Open Journal of Obstetrics and Gynecology,
Vol.12 No.5,
May
24,
2022
ABSTRACT: Aim of the study: Examing the role of Methylene tetra-hydrofolate reductase (MTHFR C677T)
polymorphisms in unexplained female infertility. Methods: The study
was conducted on women with unexplained infertility attending the Infertility Clinic
at El-Shatby University Hospital, Alexandria, during the period from October
2020 to October 2021. Uterine artery Doppler assessment and detection of MTHFR C677T gene mutation were done. The frequencies of
homozygous and heterozygous gene mutations were determined. Results: In group I, 35 cases had abnormal uterine artery Doppler compared to 22
normal cases in group II. As regards MTHFR C677T gene mutation, 19 cases were
positive in group I (7 were homozygous and 12 were heterozygous) and only one
case was positive in group II (heterozygous) which was statistically
significant. Conclusion: MTHFR C677T gene polymorphisms may play a role in unexplained
infertility.