TITLE:
Pd-Catalyzed Unprecedented Cross-Coupling of Mixed Phenols and Halides for the Synthesis of Aromatic Ethers
AUTHORS:
Mohammad Al-Masum, Reem M. Albeshy, Houra A. Alalwan
KEYWORDS:
Microwave, Ethers from Mixed Phenols, Cross-Coupling, Cascade Type Reac-tion
JOURNAL NAME:
International Journal of Organic Chemistry,
Vol.12 No.2,
May
18,
2022
ABSTRACT: Phenolic compounds present in medicinal and edible plants such as flavonoids, chalcones,
coumarins, quinones, and phenolic acids. The antioxidant potential of phenolic compounds shows
potent activities for cancer prevention and
its treatment. From a green chemistry point of view, cascade (tandem) reactions are ideal techniques in
organic synthesis for building complex structures. Cascade techniques are sometimes observed in
coupling reactions under mild conditions with a tolerance of multifunctional groups. It will be
interesting to find a cascade type reaction to synthesize polyphenolic ethers.
This research project achieves a new cross-coupling method for establishing
polyphenolic ethers from mixed phenols and halides in the presence of palladium
catalyst in moderate to good yields.