TITLE:
Teratogenic Investigation of Bay Leaf (Syzygium polyanthum Wight.) Ethanol Extract on Morphology of Fetal Mice (Mus musculus L.) Strain DDY
AUTHORS:
Marissa Angelina, Aulia Ovy, Indah D. Dewijanti, Ainul Mardhiyah, Luthfiralda Sjahfirdi
KEYWORDS:
Fetus, Mice, Organogenesis, Resorption, S. polyanthum
JOURNAL NAME:
Open Access Library Journal,
Vol.9 No.4,
April
26,
2022
ABSTRACT: This research was conducted to observe the teratogenic potential of S. polyanthum ethanol extract on morphology of fetal mice strain DDY. Thirty pregnant female mice were divided into 5 groups, normal group and treatment groups with dose 0.5; 5; 50; 500 mg/bw. The extract was given orally from 6th to 15th day of gestation. The results showed that the effect of S. polyanthum ethanol extract at a dose of 0.5 mg/bw did not cause resorption and external malformation. At a dose of 5 mg/bw, there were resorption (6.15%) and fetal open eyelids (1.63%). Resorption (7.69%; 9.34%) and fetal hemorrhage (1.63%; 1.47%) were found in mice given doses of 50 and 500 mg/bw. The treatment of S. polyanthum ethanol extract at doses 0.5; 5; 50; 500 mg/bw during the period of organogenesis did not have a significant influence on morphology of fetal mice strain DDY (p > 0.05).