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He, L., He, X.Y., Lim, L.P., Stanchina, E.D., Xuan, Z.Y., Liang, Y., Xue, W., Zender, L., Magnus, J., Ridzon, D., Jackson, A.J., Linsley, P.S., Chen, C., Lowe, S.W., Cleary, M.A. and Hannon, G.J. (2007) A MicroRNA Component of the p53 Tumour Suppressor Network. Nature, 447, 1130-1134.
https://doi.org/10.1038/nature05939

has been cited by the following article:

• TITLE: Regulation Effect of miR-34a Expression on Radiosensitivity of Lung Adenocarcinoma Cells by Targeting Bcl-2 and CDK4/6 Signaling Pathways

  AUTHORS: Xue Chen, Chen Yin, Qingfen Liu, Jianxiang Liu

  KEYWORDS: miR-34a, p53, Lung Adenocarcinoma Cells, Radiosensitivity, Cell Apoptosis, Cell Cycle

  JOURNAL NAME: Journal of Cancer Therapy, Vol.13 No.4, April 7, 2022

  ABSTRACT: Objective: Radiotherapy has been widely used to treat lung cancer. However, non-small lung cancer cells are insensitive to radiation, diminishing their radiotherapy effects. Although the radiosensitivity of the non-small lung cancer cells was reported to be enhanced through regulating miR-34a, the regulation effects of miR-34a expression on radiosensitivity of lung adenocarcinoma cells through target genes CDK4, CDK6, CyclinD1, and Bcl-2/Bax have not been systematically investigated. Methods: In this study, we investigated the effect of miR-34a expression on the Bcl-2, CDK4, and CDK6 pathways in lung adenocarcinoma cells, to provide new insights into the sensitization treatment of lung cancer. We first studied the effect of miR-34a expression on H1299 and A549 cell activity. Then to investigate the mechanisms of radiosensitivity, we focused on apoptosis, cell cycle, and target genes. Results: We find that overexpression of miR-34a in lung adenocarcinoma cells inhibits cell activity, and improves radiosensitivity. Specifically, overexpression of miR-34a suppresses the expression of target genes CDK4, CDK6, CyclinD1, and Bcl-2/Bax, which leads to cell cycle arrest and promotes apoptosis of lung adenocarcinoma cells. Conclusions: Overall, our results demonstrate that the overexpression of miR-34a enhances the radiosensitivity of lung adenocarcinoma cells, indicating that miR-34a is a sensitizer for lung adenocarcinoma radiotherapy.