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Savva, M. (2022) On the Origin of the Apparent Volume of Distribution and Its Significance in Pharmacokinetics. Journal of Biosciences and Medicines, 10, 78-98.
https://doi.org/10.4236/jbm.2022.101008

has been cited by the following article:

• TITLE: The Presence of Phases and the Inability of the Classical Compartment Models to Provide Pharmacokinetic Parameters of Physiological Significance for Lipophilic Drugs

  AUTHORS: Michalakis Savva

  KEYWORDS: Lipophilic Drugs, Pharmacokinetic Compartment Model, Apparent Volume of Distribution, Clearance, Prazosin, Doxazosin, Digoxin, Pindolol

  JOURNAL NAME: Journal of Biosciences and Medicines, Vol.10 No.4, March 31, 2022

  ABSTRACT: The first biphasic open one-compartment pharmacokinetic model is described. Its analytical solutions to drug concentration were developed from parameters of an open two-compartment pharmacokinetic model. The model is used to explain the unusually large compartment volumes and apparent volumes of distribution of lipophilic drugs, as well as to identify which of the pharmacokinetic parameters of the classical compartment models are biologically relevant.