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Denny, W.A., Rewcastle, G.W. and Baguley, B.C. (1990) Potential Antitumor Agents. 59. Structure-Activity Relationships for 2-Phenylbenzimidazole-4-Carboxamides, a New Class of Minimal DNA-Intercalating Agents Which May Not Act via Topoisomerase II. Journal of Medicinal Chemistry, 33, 814-819.
https://doi.org/10.1021/jm00164a054

has been cited by the following article:

• TITLE: Design and Synthesis of New Compounds Derived from Phenyl Hydrazine and Different Aldehydes as Anticancer Agents

  AUTHORS: Mo’men Salem, Rezk Ayyad, Helmy Sakr, Ahmed Gaafer

  KEYWORDS: Phenyl Hydrazine, Aromatic Aldehydes, Benzylidene Synthesis, Cytotoxic Assay, Anticancer, HepG2 and MCF-7

  JOURNAL NAME: International Journal of Organic Chemistry, Vol.12 No.1, March 30, 2022

  ABSTRACT: In this work we synthesized new derivatives from Phenyl Hydrazine and series of different Aldehydes (derivatives of benzylidenes). The synthesized compounds contain different aromatic Aldehydes which attached by Benzene ring via Hydrazine moiety in glacial acetic acid. These derivatives were characterized by TLC, melting points, Infrared Red, Proton Nuclear Magnetic Resonance, Carbon Thirteen Nuclear Magnetic Resonance and Mass Spectroscopy. Finally, these synthesized derivatives were tested for antiproliferative activity against multiple normal and cancerous cell lines, HepG2 (Liver cancer) and MCF-7 (Breast cancer) cell lines were used for cytotoxic assay.