TITLE:
Study on the Efficacy of Vitamin C Lotion on Skin: Permeable and Anti-Aging
AUTHORS:
Mengping Wang, Wangwang Lu, Xinye Ge, Yuan Lu, Xiwen Jia, Huiming Li, Qiaoyuan Liu
KEYWORDS:
Vitamin C Lotion, Efficacy, Transdermal Penetration, Skin Whitening, Anti-Aging
JOURNAL NAME:
Journal of Cosmetics, Dermatological Sciences and Applications,
Vol.12 No.1,
March
25,
2022
ABSTRACT: Vitamin C (ascorbic acid) plays an important role in maintaining skin health, and topical vitamin C supplementation can counteract oxidative stress induced by UVA, due to excellent reducibility. To clarify the efficacy of vitamin C on the skin in the carrier of lotion, we studied its permeability, irritation and anti-aging effect in vitro and in vivo, using Franz cell system, cell model and clinical test. The permeability test showed that vitamin C with 10%, 15%, 20% and 25% mass ratio could effectively penetrate skin. The 20% of vitamin C lotion (VCL-20%) had the highest efficiency of transdermal penetration and the diffusion percentage reached 84.707% after 24 h. Besides, the permeation quantity of VCL-20% was 1.43 times that of the control group. Irritation test showed that the cytotoxicity of vitamin C lotion was low. And no allergic reaction happened in the occlusive patch test. Compared with the control group, using vitamin C lotion for 28 days could significantly improve subjects’ skin gloss of 10.53% and improve skin color, enhance facial skin elasticity and tightness of 9.20% and reduce wrinkle area of 12.27% (p