TITLE:
Clostridium difficile Toxin B: Insights into Its Target Genes
AUTHORS:
Junyi Hu, Yunjie Shan, Huan Yang
KEYWORDS:
Clostridium difficile Infection, TcdB, Gene Regulation
JOURNAL NAME:
Open Journal of Applied Sciences,
Vol.12 No.3,
March
24,
2022
ABSTRACT: Clostridium difficile is a
grossly Gram-positive anaerobic bacterium that has been a key factor in inducing imbalances in the gut microbiota in recent years,
leading to intestinal-associated inflammation. The main pathogenic toxins of Clostridium difficile are toxin A (TcdA) and toxin B (TcdB). TcdB is
the main pathogenic factor of Clostridium difficile infection.
This review revealed the pathogenic mechanism of Clostridium difficile toxin B, expounded the impact of Clostridium difficile on the intestinal
system, and predicted the genes on which TcdB may act, thereby providing a new
therapeutic target for Clostridium difficile infection, offering
theoretical basis and new strategies for clinical prevention and control.