TITLE:
Assessment of Integrated Antioxidant Systems and Hormezis Effect of Radon in Experimental Studies
AUTHORS:
Marine Nikolaishvili, Zaqaria Nanobashvili, Nodar Mitagvaria, Gvantsa Chkadua, Tea Museliani, Khatuna Dondoladze, Gogi Jikia
KEYWORDS:
Radon, Epileptic Rats, Oxidative Stress, Sulfhydryl Groups, Na, K-ATPase
JOURNAL NAME:
Journal of Biosciences and Medicines,
Vol.10 No.3,
March
17,
2022
ABSTRACT: According to our research, the use of radon inhalation in experimental animals, particularly in genetically determined rats with epileptic seizures, altered all parameters of the epileptic seizure development picture, namely the hidden period, the first and second wild jog duration after the audiogenic signal. On the third day, no response to the audiogenic signal was observed at all, and not even a single episode of tonic-clonic seizures. All mentioned suggest that radon inhalation could be used to treat epilepsy. Presented study is the first precedent of attempt R-Ho through inhalation for treatment of epileptic seizures in animal models with further translation to clinical study in humans through pilot phase II study. More profound and scientifically systematized approach is needed to determine uniqueness of Tskhaltubo water springs, great importance investigation of the mechanisms of radon effects on the excitatory and inhibitory functioning of CNS and further clinical studies to establish its effect on humans.