TITLE:
The Study of Effect of Commercial Baicalin Combined with Cefoperazone Sulbactam Sodium on Pseudomonas aeruginosa in Vitro
AUTHORS:
Jiming Li, Meide Wei, Linghong Wang, Yanbo Wu, Lu Kang, Yan Tang, Huan Zhao, Yubiao Sun
KEYWORDS:
Baicalin, Cefoperazone-Sulbactam Sodium, Combined Use, Pseudomonas aeruginosa, Drug Resistance, Antibacterial
JOURNAL NAME:
Natural Science,
Vol.14 No.3,
March
7,
2022
ABSTRACT: Objective: To investigate the antibacterial effect of baicalin combined with cefoperazone-sulbactam sodium on drug-resistant strains of Pseudomonas aeruginosa. Method: Pseudomonas aeruginosa strains that are sensitive and resistant to cefoperazone-sulbactam sodium were selected to prepare different test bacterial solutions respectively; The test solutions of baicalin and cefoperazone sulbactam sodium were prepared respectively, and different test groups and control groups were set up; The drug sensitivity tests of different concentration gradients of baicalin and cefoperazone sulbactam sodium used alone and in combination were carried out for different sensitive and drug-resistant strains, and the standard strains were used as parallel control. Result: The drug susceptibility test results of the combined use of baicalin and cefoperazone-sulbactam against Pseudomonas aeruginosa drug-resistant strains were compared with the drug susceptibility results of the two used separately, and the difference was statistically significant (P Pseudomonas aeruginosa.