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Gong, G.W., Wang, H.Y., Kong, X.P., et al. (2018) Flavonoids Are Identified from the Extract of Scutellariae Radix to Suppress Inflammatory-Induced Angiogenic Responses in Cultured RAW 264.7 Macrophages. Scientific Reports, 8, Article No. 17412.
https://doi.org/10.1038/s41598-018-35817-2

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• TITLE: Target Prediction of Xinyi San for Rhinitis Based on Network Pharmacology

  AUTHORS: Lingdi Wang, Ying Wang, Yingxue Lin, Xin Meng

  KEYWORDS: Rhinitis, Network Pharmacology, Xinyi San

  JOURNAL NAME: Chinese Medicine, Vol.13 No.1, March 2, 2022

  ABSTRACT: Objective: To analyze the potential mechanism of Xinyi San in treating rhinitis through network pharmacology. Methods: In the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical composition and potential targets of Xinyi San were got, and the target genes of rhinitis of Xinyi San were extracted from GeneCards databases. Then we constructed protein-protein interactions (PPI) network of target genes, and then analyzed the Key genes in GO analysis and KEGG analysis. Results: We got 97 components, 53 potential therapeutic targets, 1009 GO items and 92 pathways in our study. The main pathways included Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt signaling pathway, Human cytomegalovirus infection, Prostate cancer, etc. Conclusion: Xinyi San plays a role in treating rhinitis through multiple components, multiple targets and multiple pathways.