TITLE:
Target Prediction of Xinyi San for Rhinitis Based on Network Pharmacology
AUTHORS:
Lingdi Wang, Ying Wang, Yingxue Lin, Xin Meng
KEYWORDS:
Rhinitis, Network Pharmacology, Xinyi San
JOURNAL NAME:
Chinese Medicine,
Vol.13 No.1,
March
2,
2022
ABSTRACT: Objective: To analyze the potential mechanism of Xinyi San in treating
rhinitis through network pharmacology. Methods: In
the database of Traditional Chinese Medicine Systems Pharmacology (TCMSP), chemical
composition and potential targets of Xinyi San were got,
and the target genes of rhinitis of Xinyi San were extracted from GeneCards
databases. Then we constructed protein-protein interactions (PPI)
network of target genes, and then analyzed the Key genes in GO analysis and
KEGG analysis. Results: We got 97 components, 53
potential therapeutic targets, 1009 GO items and 92 pathways in our study. The
main pathways included Lipid and atherosclerosis, Chemical carcinogenesis-receptor activation, PI3K-Akt
signaling pathway, Human cytomegalovirus infection, Prostate cancer, etc. Conclusion: Xinyi San plays a role in treating rhinitis through multiple components, multiple targets and multiple pathways.