TITLE:
Evaluation of Red Blood Cell Contribution to Platelet Activation in the Bulk Applying Red Blood Cell—Platelet Thrombus as a Point Source Model
AUTHORS:
Taha M. Alkhamis, Bahieh M. Alma’atah
KEYWORDS:
Platelet, Red Blood Cell, Aggregation, Adhesion, Diffusion, ADP, Point Source, Chemical Contribution, Physical Contribution, Shear Stresses, Hemolysis
JOURNAL NAME:
Advances in Bioscience and Biotechnology,
Vol.13 No.2,
February
24,
2022
ABSTRACT: In this study, a point source mathematical model is
proposed to describe the diffusion of adenosine di-phosphate (ADP) from either
damaged red blood cell (RBC) or activated platelet. The convective diffusion
equation is reduced
to describe the suggested problem. The final differential equation is solved
using Laplace transforms and ADP concentration profiles around the source are
obtained. Thrombi of 5 to 20 μm3 containing platelets and a range of
red blood cells (RBCs) (0%, 25%, 50%, 75%, 100%) concentrations are used to
apply the model. Reported ADP concentrations in the literature are used and its
dynamic release from the point source is calculated. Results suggest that RBC
chemical contribution to platelet aggregation in the bulk is much less than
that of platelet (almost) negligible. However, the physical effect of RBCs is
dominant in the bulk through augmentation of released ADP and platelets
diffusivities. Moreover, the chemical contribution reported in previous studies
is suggested to be as a result of interaction of RBC with the surface under the
influence of shear stresses in the boundary region.