TITLE:
Particularities of Tuberculosis in Children and Adolescents with Sickle Cell Disease in Senegal
AUTHORS:
Idrissa Demba Ba, Indou Deme/Ly, Yaye Joor Dieng, Abou Ba, Babacar Niang, Aliou Abdoulaye Ndongo, Papa Moctar Faye, Guillaye Diagne, Amadou Sow, Fatima Tall/Fall, Amadou Lamine Fall, Ousmane Ndiaye
KEYWORDS:
Tuberculosis, Sickle Cell Disease, Children, Adolescent, Senegal
JOURNAL NAME:
Open Journal of Pediatrics,
Vol.12 No.1,
February
15,
2022
ABSTRACT: Introduction: Tuberculosis and sickle cell disease are one of the main global health
priorities particularly in Africa. We aimed to determine the epidemiological, diagnostic and therapeutic aspects of
tuberculosis in children and adolescents with sickle cell disease. Patients
and methods: Patients aged 0 - 20 years with sickle cell anemia presented with tuberculosis at the Centre Hospitalier National d’Enfants Albert Royer
(CHNEAR), Dakar, Senegal were included in the study. Medical history, risk
factors, clinical, bacteriological, and outcome data was collected. Data was
analyzed using the SPSS software, version 16. Results: A total of 25
cases of tuberculosis were documented from January 1st, 1991 to December 31st,
2019 (hospital prevalence: 0.97%). Mean age was 12.5 years.
The sex ratio was 1.5 (15 girls and 10 boys). Pulmonary tuberculosis in 14 cases was the most frequent followed by lymph nodes in 7 cases
involvement and Pott’s disease in 4 cases. In 5 patients Tb was multifocal.
Mean duration of treatment was 8.27 months (6 to 12 months). Outcome was good
on antituberculosis treatment. None patient died. Conclusion: Children
and adolescents with sickle cell disease can be infected with Mycobacterium
tuberculosis. Pulmonary tuberculosis, lymph nodes and bone involvement are
the most frequent localizations. Outcome is good on antituberculosis treatment.