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Delpassand, E., Tworowska, I., Shanoon, F., Nunez, R., Flores, L., Muzammil, A., Stallons, T., Saidi, A. and Torgue, J. (2019) First Clinical Experience Using Targeted Alpha-Emitter Therapy with Pb-212-DOTAMTATE (AlphaMedix TM) in Patients with SSTR(+) Neuroendocrine Tumors. Journal of Nuclear Medicine, 60, 559.

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• TITLE: Synthesis and Stability Studies of 225Actinium Tin Colloid Radiopharmaceutical

  AUTHORS: Davut Cakici, Benan Kilbas

  KEYWORDS: 225Actinium Tin Colloid, Radiosynovectomy, Stability, Targeted Alpha-Particle Therapy

  JOURNAL NAME: Advances in Nanoparticles, Vol.11 No.1, February 11, 2022

  ABSTRACT: Synthesis of novel 225Ac-Sn particles was described for the first time. Detailed experimental and stability studies were successfully exhibited. Treatment of excess amount of SnCl2 with 0.2 mCi 225Ac furnished highly stable 225Ac tin colloid with 90% of radiochemical yield (RCY) at optimized reaction condition. R-TLC analyses indicated 95% of radiochemical purity (RCP). Stability studies showed that colloidal structure also retained free daughter radionuclides formed by the 225Ac decay chain. 225Ac tin colloids could be ideal nanocarriers for localized cell killing due to high linear energy transfer and prevention of free radioisotope daughters.