TITLE:
Male Breast Cancer: Diagnostic and Prognostic Features in Mali
AUTHORS:
Iriss A. Darar, Zakari Saye, Bourama Diarra, Madiassa Konaté, Amadou Traoré, Seydou Pamateck, Abdillahi I. Ismail, Arouna Adama Doumbia, Boubacar Karembé, Bakary Tientigui Dembélé, Lassana Kanté, Drissa Traoré, Zimogo Zié Sanogo, Alhassane Traoré, Adégné Togo
KEYWORDS:
Breast Cancer, Diagnostic Aspect, Male, Mali, Therapeutic Aspect
JOURNAL NAME:
Journal of Cancer Therapy,
Vol.13 No.2,
February
9,
2022
ABSTRACT: Introduction: Male breast cancer is rare; representing 1% of breast cancers and less
than 1% of all male neoplasia worldwide. We here analyzed the clinical, histological, therapeutic and prognostic
characteristics of male breast cancer in Bamako, Mali. Patients
and methods: A retrospective descriptive
study was conducted on
14 male patients with breast cancer who visited two university hospitals
in Bamako (Hospital Gabriel TOURE and Hospital du Point G) in Mali, from
January 2005 to December 2018. Results: Male breast cancer represented 0.63%
of all breast cancers and 0.23% of all male cancers. The following was
observed: the mean age of 53 years (range: 23 - 82); a family history of cancer in 2; breast pain in 9; the average time
to consultation of 8 years (6 - 24); gynecomastia found in 1; the tumor palpable in
all 14 (size of 5 cm [3 - 10]); ulceration in 5. The most common histological type was non-specific infiltrating carcinoma with 92.8%.
SBR II grade was found in 78.5% of cases. Of 8 patients with immunohistochemistry, hormone receptor positive was in 13 and Her2
positive was in 5. Metastases were found in 4, 2 pulmonary and 2 hepatic. Treatment: Neoadjuvant chemotherapy in
21.4%; radical surgery in 13 cases; surgery + radiotherapy in 2; surgery
+ hormonal therapy in 4. After an average
follow-up of 36 months, 1 patient developed a lung metastasis and another
patient had a lymph node recurrence. Conclusion: Male breast cancer was detected at relatively later stages. Physicians
must be aware of this condition.