TITLE:
Meta-Analysis of Multi-Arm Trials Using Binomial Approach
AUTHORS:
Hathaikan Chootrakool, Pichet Treewai
KEYWORDS:
Meta-Analysis, Multi-Arm Trials, Binomial Approach
JOURNAL NAME:
Open Journal of Statistics,
Vol.12 No.1,
February
7,
2022
ABSTRACT: Most meta-analysis has concentrated on combining of treatment effect
measures based on comparisons of two treatments. Meta-analysis of multi-arm
trials is a key component of submission to summarize evidence from all possible
studies. In this paper, an exact binomial model is proposed by using logistic
regression model to compare different treatment in multi-arm trials. Two
approaches such as unconditional maximum likelihood and conditional maximum
likelihood have been determined and compared for the logistic regression model.
The proposed models are performed using the data from 27 randomized clinical
trials (RCTs) which determine the efficacy of antiplatelet therapy in reduction
venous thrombosis and pulmonary embolism.