Article citationsMore>>

Sonderup, M.W., Afihene, M., Ally, R., Apica, B., Awuku, Y., Cunha, L., Dusheiko, G., Gogela, N., Marie-Lohouès-Kouacou, J., Lam, P., Lesi, O., Mbaye, P.S., Musau, E.M.B., Ojo, O., Rwegasha, J., Scholz, B., Shewaye, A.B., Tzeuton, C., Kassianides, C. and Spearman, C.W. (2017) Hepatitis C in Sub-Saharan Africa: The Current Status and Recommendations for Achieving Elimination by 2030. The Lancet Gastroenterology and Hepatology, 2, 910-919.
https://doi.org/10.1016/S2468-1253(17)30249-2

has been cited by the following article:

• TITLE: Hepatitis B and C Immunological and Molecular Parameter Analysis in HIV-Positive Patients Undergoing Antiretroviral Therapy at Saint Camille Hospital in Ouagadougou (HOSCO), Burkina Faso

  AUTHORS: Denise P. Ilboudo, W. W. Eudoxie Kévine Savadogo, Théodora M. Zohoncon, Estelle Savadogo, Yéri Esther Hien, Lassina Traore, Djéneba Ouermi, Wendkuuni Florencia Djigma, Christelle M. Nadembega, Marius Belemgnegre, Paul Ouedraogo, Mahamoudou Sanou, Damintoti Simplice Karou, Yves Traore, Jacques Simpore

  KEYWORDS: HIV, Clinical-Biological Profile, Hepatitis B and C, Co-Infection, Burkina Faso

  JOURNAL NAME: Advances in Infectious Diseases, Vol.12 No.1, January 27, 2022

  ABSTRACT: Knowledge of the clinical and biological profile of patients infected with HIV and hepatitis B and/or C is essential in order to identify and implement effective management strategies. Methods: This was a retrospective descriptive study from January 01, 2016 to June 01, 2021. Adult patients aged at least 18 years infected with HIV type 1 and/or 2, na?ve to ARV treatment. Univariate analyses were assessed using Pearson’s Chi2 test. The Student Newman test was used for comparison between groups using R software version 4.0.2. Objective: To draw up the epidemiological, clinical, paraclinical and evolutionary profiles of HIV-treated-patients in relation to HIV/HBV and HIV/HCV co-infections in order to allow the identification and the implementation of effective management strategies. Results: Of the 379 patients included 280 (73.88%) were women. At treatment initiation, the mean age was 40.14 ± 11.84 years. The majority of patients consulted at WHO stage III (51.45%). Clinical suspicion was the most frequent screening circumstance (51.71%). The pathologies frequently reported at the first consultation were diarrhea (28%) and shingles (16%). Body mass index was normal in 50.5% of patients. HIV1 infection was the majority (91.03%). A total of 270 had a CD4 count at treatment initiation. The mean CD4 cell count was 304.17 ± 242.06 cells/μL, and 116 (42.59%) of them had a CD4 ≤ 200 cells/μL. Viral load at treatment initiation was documented in 62 patients (16.35%) and 70.97% of them had a detectable viral load (greater than 1000 copies/mL). The clinical and biological evolution was relatively good in patients after therapeutic initiation. HIV-HBV co-infection was 24.11% and HIV-HCV co-infection was 2.26%. The mortality rate was 3.69%. Conclusion: These results reflect a significant delay in HIV infection diagnosis. Furthermore, hepatitis B and/or C is co-infections that increasingly affect people living with HIV. It also appears that COVID 19 disease has had a strong impact on patient management. Thus, new screening strategies must be implemented to encourage early diagnosis of HIV, hepatitis B and C. Effective strategies are also necessary to fight HIV in the context of epidemics and/or pandemics.