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Zhang, Y.N., Yin, H.M., Zhang, Y., et al. (2015) Synthesis and Characterization of Pharmaceutical Co-Crystal of Luteolin with 4,4’-Dipyridy. Journal of Northeast Agricultural University, 46, 72-78.

has been cited by the following article:

• TITLE: The Research Progress on Cocrystals of Flavonoids

  AUTHORS: Yingfan Xia, Renjie Xu, Chengjun Jiang

  KEYWORDS: Flavonoids, Cocrystal Technology, Traditional Chinese Medicine, Hydrogen Bond, Drug Absorption, Bioavailability

  JOURNAL NAME: Open Access Library Journal, Vol.9 No.1, January 24, 2022

  ABSTRACT: Flavonoids are an important class of natural organic compounds that widely exist in nature and have rich medicinal value. Cocrystal technology is an effective method to improve the solubility of insoluble flavonoids. The cocrystal formers and the hydroxyl groups in the flavonoid compound form a new crystal structure through hydrogen bonding, and the original lattice packing and molecular arrangement have changed. On the premise of not changing the active ingredients of the drug, the solubility of the drug is improved, thereby improving the drug absorption and increasing the bioavailability. This article reviews the research progress of drug cocrystals of flavonoids, and provides a reference for the application of flavonoids in medicine.