TITLE:
Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods
AUTHORS:
Baktygul Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, Gulsara Zhusupbaeva, Orozby Akparalieva, Zhypargul Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, Galina Apryshko, Alina Orozmatova
KEYWORDS:
Biological Activity, Synthesis, Urea, Carbohydrate, Compounds, Hyperurcemia, Ototoxicity, Testing, Toxicity, Anti Tuberculosis, Antitumor
JOURNAL NAME:
Journal of Agricultural Chemistry and Environment,
Vol.11 No.1,
January
20,
2022
ABSTRACT: Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.