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Ernazarova, B., Dzhumanazarova, A., Bakirova, A., Abdullaeva, Z., Zhusupbaeva, G., Asylbek Kyzy, Z. and Arzybaev, M. (2020) Synthesis, Assessment of Biological Activity and Toxicity for N-(β-D-Glycopyranosyl)-Thiosemicarbazides. International Journal of Organic Chemistry, 10, 159-169.
https://doi.org/10.4236/ijoc.2020.104012

has been cited by the following article:

• TITLE: Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods

  AUTHORS: Baktygul Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, Gulsara Zhusupbaeva, Orozby Akparalieva, Zhypargul Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, Galina Apryshko, Alina Orozmatova

  KEYWORDS: Biological Activity, Synthesis, Urea, Carbohydrate, Compounds, Hyperurcemia, Ototoxicity, Testing, Toxicity, Anti Tuberculosis, Antitumor

  JOURNAL NAME: Journal of Agricultural Chemistry and Environment, Vol.11 No.1, January 20, 2022

  ABSTRACT: Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.