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Pitucha, M., Karczmarzyk, Z., Swatko-Ossor, M., Wysocki, W., Wos, M., Chudzik, K., Ginalska, G. and Fruzinski, A. (2019) Synthesis, in Vitro Screening and Docking Studies of New Thiosemicarbazide Derivatives as Antitubercular Agents. Molecules, 24, Article No. 251.
https://doi.org/10.3390/molecules24020251

has been cited by the following article:

• TITLE: Study of Biological Activity and Toxicity of Thiosemicarbazides Carbohydrate Derivatives by in Silico, in Vitro and in Vivo Methods

  AUTHORS: Baktygul Ernazarova, Taitokur Zhusubaliev, Zarylkan Asilbek kyzy, Aida Bakirova, Gulsara Zhusupbaeva, Orozby Akparalieva, Zhypargul Abdullaeva, Nasibakhon Razykova, Asilkan Dzhumanazarova, Galina Apryshko, Alina Orozmatova

  KEYWORDS: Biological Activity, Synthesis, Urea, Carbohydrate, Compounds, Hyperurcemia, Ototoxicity, Testing, Toxicity, Anti Tuberculosis, Antitumor

  JOURNAL NAME: Journal of Agricultural Chemistry and Environment, Vol.11 No.1, January 20, 2022

  ABSTRACT: Computer analysis of N-(β-D-galactopyranosyl)-thiosemicarbazide compounds by in silico method revealed high probability of antibacterial (antimycobacterial), anti-tuberculosis (antituberculosic), antiviral (Influenza), antitumor (antineoplastic) 9 > Pa > 0.5 and with a low probability of cytotoxic/cytostatic (cytostatic/cytotoxic) activities. An experimental study by in vitro and in vivo methods allowed us to conclude that studied new synthetic compound N-(β-D-galactopyranosyl)-thiosemicarbazide in the studied concentrations has a pronounced bactericidal and bacteriostatic effects.